反应详情

温度

85 °C

To a stirred solution of 0.26 g (0.90 mmol) N-(3-benzoyl-benzo[b]thiophen-2-yl)-acetamide in 20 ml ethanol was added 1 ml aqueous sodium hydroxide (1 M). The mixture was heated at 85° C. for 1 hour and then poured onto water and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated in vacuo. Flash chromatography (heptane/ethyl acetate 6:1) afforded 65 mg (25%) (2-amino-benzo[b]thiophen-3-yl)-phenyl-methanone as an orange solid. ES-MS m/e (%): 254 (M+H+, 100).

1. additionpoured onto water
2. extractionextracted three times with ethyl acetate
3. dry with materialThe combined organic phases were dried over sodium sulfate
4. concentrationconcentrated in vacuo