Hydrochloric Acid → 3-[4-(Methanesulfonyl)phenyl]-3-oxopropanenitrile

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Reaction Steps

To a stirred suspension of 1.0 g (3.61 mmol) (4-methanesulfonyl-phenyl)-acetyl bromide in 15 ml ethanol was added a solution of 0.47 g (7.22 mmol) potassium cyanide in 5 ml water. The mixture was then stirred at RT for 1 h, then acidified to ph=5-6 with aqueous HCl 1M and then extracted with ethyl acetate, The combined organic phases were dried over sodium sulfate and concentrated in vacuo to afford 0.29 g (37%) 3-(4-methanesulfonyl-phenyl)-3-oxo-propionitrile as a yellow solid. ES-MS m/e (%): 222 (M, 100).

Provenance & Evidence