HCID 9813406, compound → HCID 11515326, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 60 mg (0.26 mmol) (2-amino-5,6-dihydro-4H-cyclopenta [b]thiophen-3-yl)-furan-2-yl-methanone (the preparation of which is described in example 18) in 2 ml acetic acid was added 43 mg (0.34 mmol) of 1-cyclopropyl-butane-1,3-dione and one drop of sulfuric acid. The mixture was then stirred at 100° C. for 10 minutes in a microwave and then concentrated in vacuo. Preparative HPLC (30% CH3CN/H20) afforded 17 mg (21%) cyclopropyl-(4-furan-2-yl-2-methyl-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-b]pyridin-3-yl)-methanone as a light brown solid. ES-MS m/e (%): 324 (M+H+, 100).

Provenance & Evidence