HCID 10805283, compound → HCID 11524270, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 60 mg (0.19 mmol) 4-(2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carbonyl)-benzoic acid methyl ester in 2 ml acetic acid was added 32 mg (0.25 mmol) of 1-cyclopropyl-butane-1,3-dione and one drop of sulfuric acid. The mixture was then stirred at 100° C. for 10 minutes in a microwave and then concentrated in vacuo. Preparative HPLC (30% CH3CN/H20) afforded 28 mg (37%) 4-(3-cyclopropanecarbonyl-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-b]pyridin-4-yl)-benzoic acid methyl ester as a light pink solid. ES-MS m/e (%): 406 (M+H+, 100).

Provenance & Evidence