Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1335471Generated: November 2, 2026

3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine

https://huagongshe.com/reaction/1335471

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
Catalyst1,2-Bis(diphenylphosphino)ethaneHCID 74267—
CatalystHCID 178427212HCID 178427212—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802230%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883370.621%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-25a6e09e3a3b4fb8909855d832f7f508
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions