HCID 69214710, compound → HCID 508915, compound

Participants

Reaction Steps

A mixture of (R)-3-[[N-(2-amino-5-trifluoromethylbenzoyl)glycyl]amino]-1-(4,5-methylenedioxy-2-nitrobenzyl)pyrrolidine (30.5 mg) with 10% Pd carbon (6 mg) and methanol (3 mL) was stirred at room temperature under a hydrogen atmosphere for 10 hours. The palladium catalyst was filtered through Celite, and the filtrate was concentrated and purified by solid-phase extraction (Bond Elut™ SI, 20% methanol/ethyl acetate) to thereby afford (R)-1-(2-amino-4,5-methylenedioxybenzyl)-3-[[N2-amino-5-trifluoromethylbenzoyl]glycyl]amino]pyrrolidine (Compd. No. 2127) (21.9 mg, 76%). The purity was determined by RPLC/MS (95%). ESI/MS m/e 480.1 (M++H, C22H24F3N5O4).

Provenance & Evidence