Ethyl Acetate → HCID 44453405, compound

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A mixture of (R)-3-[[N-(2-amino-5-trifluoromethylbenzoyl)glycyl]amino]-1-(4-chloro-3-nitrobenzyl)pyrrolidine (32.6 mg) with 10% palladium carbon (8 mg), ethyl acetate (2.7 mL) and methanol (0.3 mL) was stirred at room temperature under a hydrogen atmosphere for 15 hours. The palladium carbon was removed by filtration, and the filtrate was concentrated and purified by solid-phase extraction (Bond Elut™ SI, 20% methanol/ethyl acetate) to thereby provide (R)-1-(3-amino-4-chlorobenzyl)-3-[[N-(2-amino-5-trifluoromethylbenzoyl)glycyl]amino]pyrrolidine (Comp d. No. 2132) (10.5 mg, 34%). The purity was determined by RPLC/MS (84%). ESI/MS m/e 470.2 (M++H, C21H23F3N5O2).

Provenance & Evidence