HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1335721Generated: October 29, 2026
3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine
https://huagongshe.com/reaction/1335721
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | Sodium trimethylsilanolate | HCID 23672319 | — |
| Catalyst | Nickel(II) iodide | HCID 26038 | — |
| Catalyst | 2-((2,6-Dimethoxyphenyl)amino)-2-oxoacetic acid | HCID 118864503 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 1.611% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 2.037% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-1db4ed1380b447708a30aa5c2c4afc70 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
