1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 18426157, compound

Participants

Reaction Conditions

Reaction Steps

N-(3-Methylbenzoyl)glycine (10.6 mg, 0.055 mmol), EDCI (10.5 mg) and 1-hydroxybenzotriazole hydrate (7.4 g) were added to a chloroform (2.5 mL) solution of 1-(4-chlorobenzyl)-3-aminopiperidine dihydrochloride (1.49 mg, 0.050 mmol) and triethylamine (15.2 mg). The resulting reaction mixture was stirred at 25° C. for 16 hours and washed with a 2 N aqueous solution of NaOH (2 mL×2) and brine (1 mL). After filtration through a PTFE membrane, the solvent was removed under reduced pressure to provide 1-(4-chlorobenzyl)-3-[[N-(3-methylbenzoyl)glycyl]amino]piperidine (Compd. No. 355) (17.4 mg, 87%). The purity was determined by RPLC/MS (97%). ESI/MS m/e 400.0 (M++H, C22H26ClN3O2).

Provenance & Evidence