反应详情

温度

25 °C

1-(4-Chlorobenzyl)-4-[[(N-Boc-valyl)amino]methyl]piperidine (1.1 g, 2.51 mmol) was dissolved in a 3 M HCl-methanol solution (25 mL) and stirred at 25° C. for 1 hour. The resulting reaction mixture was concentrated, and the obtained salt was dissolved in tBuOH/H2O=3:1 (25 mL). An anion (OH−) exchange resin was added until the solution became slightly basic. The obtained mixture was filtered and concentrated to provide 1-(4-chlorobenzyl)-4-[(valylamino)methyl]piperidine (819 mg, 97%). Further purification was not required for the resulting compound. ESI/MS m/e 338.1 (M++H, C18H28ClN3O).

1. customThe resulting reaction mixture
2. concentrationwas concentrated
3. dissolutionthe obtained salt was dissolved in tBuOH/H2O=3:1 (25 mL)
4. additionAn anion (OH−) exchange resin was added until the solution
5. filtrationThe obtained mixture was filtered
6. concentrationconcentrated