HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[[N-(9-fluorenylmethyloxycarbonyl)glycyl]aminomethyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-[{N-(9-fluorenylmethyloxycarbonyl)glycyl}aminomethyl]piperidine | HCID 54127009 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[[N-(9-fluorenylmethyloxycarbonyl)glycyl]aminomethyl]piperidine | HCID 54359471 | 152.4% |
Reaction Steps
1-(tert-Butoxycarbonyl)-4-[[N-(9-fluorenylmethyloxycarbonyl)glycyl]aminomethyl]piperidine (3.17 g, 6.42 mmol) was added to a 4 M dioxane solution of HCl. The resulting solution was stirred at room temperature for 5 hours and concentrated to afford 4-[[N-(9-fluorenylmethyloxycarbonyl)glycyl]aminomethyl]piperidine (3.85 g) as an off-white solid. The obtained product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390830B1 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-aa74086fd33a4b76b2784be2b654dc1a |
| Source note | uspto-grants-2008_06 |