Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1335921Generated: October 28, 2026

3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine

https://huagongshe.com/reaction/1335921

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
CatalystHCID 178454876HCID 178454876—
CatalystHCID 178516676HCID 178516676—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802230%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883370.474%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-c1ba53861c6948b2a830666b9546b09b
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions