HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 133598Generated: October 26, 2026
Piperidine → 1-(4-Chlorobenzyl)-4-[{(4-isopropylphenylsulfonyl)glycyl}aminomethyl]piperidine
https://huagongshe.com/reaction/133598
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-(Propan-2-yl)benzene-1-sulfonyl chloride | HCID 2734882 | — |
| Reactant | 1-(4-Chlorobenzyl)-4-((glycylamino)methyl}piperidine | HCID 18426155 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-(4-Chlorobenzyl)-4-[{(4-isopropylphenylsulfonyl)glycyl}aminomethyl]piperidine | HCID 18426209 | — |
Reaction Steps
A (piperidinomethyl)polystyrene resin (28 mg, 2.8 mmol/g) and 4-isopropylbenzenesulfonyl chloride (1.5 equivalents) were added to a chloroform (2 mL) solution of 1-(4-chlorobenzyl)-4-[(glycylamino)methyl]piperidine (14.8 mg, 0.05 mmol). The resulting mixture was stirred at 25° C. for 16 hours, then filtered and concentrated to thereby afford 1-(4-chlorobenzyl)-4-[[N-(4-isopropylphenylsulfonyl)glycyl]aminomethyl]piperidine (Compd. No. 869) (22.1 mg, 92%). The purity was determined by RPLC/MS (86%). ESI/MS m/e 478 (M++H, C24H32N3O3S).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07390830B1 |
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| Source dataset | uspto-grants-2008_06 |
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| ORD ID | ord-26cd6a46834149cd9be198a7ae44bc5c |
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| Source note | uspto-grants-2008_06 |
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