HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1336031Generated: October 30, 2026
3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine
https://huagongshe.com/reaction/1336031
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | 2-Propanol, 2-methyl-, lithium salt (1:1) | HCID 23664764 | — |
| Catalyst | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 10.277% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 9.13% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-68d9051f8351487d8360d92b7b78fd1a |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
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