HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1336057Generated: October 30, 2026
3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine
https://huagongshe.com/reaction/1336057
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | 2-Propanol, 2-methyl-, lithium salt (1:1) | HCID 23664764 | — |
| Catalyst | Nickel(II) iodide | HCID 26038 | — |
| Catalyst | Methyldiphenylphosphine | HCID 73879 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 7.327% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 8.761% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-b7e3b776a1b74d6793a809d4bf67d84f |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
