反应详情

温度

-78 °C

0.1 ml of methyl lithium (1.0 M diethyl ether solution) was added to a tetrahydrofuran (1.5 ml) solution of 15.0 mg of 1-(2-(6-(6-acetyl-pyridin-3-yloxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone obtained in Example 341, at −78° C., and the reaction liquid was stirred at −78° C. for 30 minutes. The reaction liquid was poured into aqueous saturated ammonium chloride solution, extracted with chloroform, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol=7.5/1) to obtain the entitled compound as a yellow solid.

1. customthe reaction liquid
2. customThe reaction liquid
3. extractionextracted with chloroform
4. dry with materialdried with anhydrous magnesium sulfate
5. customThe solvent was evaporated away under reduced pressure
6. customthe resulting residue was purified through silica gel column chromatography (developing solvent: chloroform/methanol=7.5/1)