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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1336207Generated: November 1, 2026

3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1336207

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
Reagent2-Propanol, 2-methyl-, lithium salt (1:1)HCID 23664764—
CatalystHCID 178516676HCID 178516676—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802237.034%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883376.556%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-771d7727f96e4208bea69f414118508d
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions