Thionyl Chloride → HCID 18426175, compound

Participants

Reaction Steps

A mixture of 1-(4-carboxybenzyl)-4-[[N-(3-(trifluoromethyl)benzoyl)glycyl]aminomethyl]piperidine (240 mg) with thionyl chloride (1 mL) was stirred at room temperature for 12 hours, and the excess thionyl chloride was removed under reduced pressure to thereby afford 1-[4-(chloroformyl)benzyl]-4-[[N-(3-(trifluoromethyl)benzoyl)glycyl]aminomethyl]piperidine. The resulting acid chloride was used without being further purified.

Provenance & Evidence