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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13366Generated: October 25, 2026

(S)-Pyrrolidine-2-carboxamide monohydrochloride → (2S)-1-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxamide

https://huagongshe.com/reaction/13366

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-Pyrrolidine-2-carboxamide monohydrochlorideHCID 12707183—
Reactant5-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 23145140—
Product(2S)-1-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxamideHCID 67482658—

Reaction Steps

The entitled compound was obtained as a pale yellow solid in the same method as in Example 15 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14, and L-prolinamide hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728025B2
Source datasetuspto-grants-2010_06
ORD IDord-709c9c22110f417db56b65f4de5fc2ca
Source noteuspto-grants-2010_06