Acetic Anhydride → HCID 11258953, compound

Participants

Reaction Steps

A solution of 4-[6-(4-trifluoromethyl-phenyl)-pyrazin-2-yloxy]-benzothiazol-2-ylamine (42 mg, 0.11 mmol), acetic anhydride (50 uL, 0.53 mmol) and pyridine (2 mL) was heated at 70° C. for 18 h. The solution was concentrated under a N2 stream and the resulting solid was purified by prep LC (10-90% CH3CN/H2O modified with 0.1% TFA) to give N-{4-[6-(4-trifluoromethyl-phenyl)-pyrazin-2-yloxy]-benzothiazol-2-yl}-acetamide as a white solid [MS (ESI, pos. ion) m/z: 431 (M+1)].

Provenance & Evidence