5-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole → (2R)-1-(6-(4-Methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxylic acid methoxy-methyl-amide

HRID 13369Notes

Reaction equation

HRID 13369 reaction equation
C(OC(C1C=CC=CC=1O[C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[NH:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[N:15][C:11]=2[CH:10]=1)=O)C.[CH3:39][O:40][N:41]([CH3:49])[C:42](=[O:48])[C@H:43]1[CH2:47][CH2:46][CH2:45][NH:44]1>>[CH3:39][O:40][N:41]([CH3:49])[C:42]([C@H:43]1[CH2:47][CH2:46][CH2:45][N:44]1[C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[N:13]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[NH:15][C:11]=2[CH:10]=1)=[O:48]

Participants

3

Reactant 2

HCID 231451405-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 86619210(R)-N-methoxy-N-methylprolinamide

Product 1

HCID 86619209(2R)-1-(6-(4-Methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxylic acid methoxy-methyl-amide

Procedure

The entitled compound was obtained in the same method as in Example 15 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14, and (R)—N-methoxy-N-methylprolinamide.

Workup

  1. customThe entitled compound was obtained in the same method as in Example 15 or in accordance with the method

Sources & evidence

ORD record
ord-d23f453932ce467ab722914a811b2947
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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