5-Fluoro-4-(4-ethanesulfonyl-phenoxy)-2-nitro-phenylamine → (2R)-1-(1-(6-(4-ethanesulfonyl-phenoxy)-2-pyrrolidin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-2-yl)-ethanone
Reaction equation
F[C:2]1[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH2:22][CH3:23])(=[O:21])=[O:20])=[CH:15][CH:14]=2)=[CH:4][C:5]([N+:9]([O-])=O)=[C:6]([NH2:8])[CH:7]=1.[NH:24]1[CH2:28][CH2:27][CH2:26][CH:25]1[C@H:29]([OH:31])[CH3:30]>>[CH2:22]([S:19]([C:16]1[CH:17]=[CH:18][C:13]([O:12][C:3]2[C:2]([N:24]3[CH2:28][CH2:27][CH2:26][C@@H:25]3[C:29](=[O:31])[CH3:30])=[CH:7][C:6]3[NH:8][C:29]([CH:25]4[CH2:26][CH2:27][CH2:28][NH:24]4)=[N:9][C:5]=3[CH:4]=2)=[CH:14][CH:15]=1)(=[O:21])=[O:20])[CH3:23]Participants
3
Procedure
The entitled compound was obtained as a pale yellow solid in the same method as in Example 369 or in accordance with the method or by combining it with an ordinary method but using 4-(4-ethanesulfonyl-phenoxy)-5-fluoro-2-nitro-phenylamine obtained in Example 259 (step 1) and 1-(R)-pyrrolidin-2-yl-ethanol.
Workup
- customThe entitled compound was obtained as a pale yellow solid in the same method as in Example 369 or in accordance with the method
Sources & evidence
- ORD record
- ord-5dc1bab9c38d4808b86d3c6d056d7f02
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07728025B2
Reaction notes
Loading…