4-Fluorophenol → HCID 21024450, compound

HRID 133765Notes

Reaction equation

HRID 133765 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]2([CH3:22])[CH2:21][O:20]2)=[O:18])=[CH:12][C:11]=1[CH3:23]>>[F:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:18])[C:19]([OH:20])([CH3:21])[CH2:22][O:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:12][C:11]=1[CH3:23]

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 45097138HCID 45097138, compound

Product 1

HCID 21024450HCID 21024450, compound

Procedure

N-(4-Fluoro-3-methylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide was prepared as described in Example 1c starting from 4-fluorophenol and 2-methyloxirane-2-carboxylic acid (4-fluoro-3-methylphenyl)amide. The crude product was purified by flash chromatography (dichloromethane-1.4% methanol).

Workup

  1. customThe crude product was purified by flash chromatography (dichloromethane-1.4% methanol)

Sources & evidence

ORD record
ord-3e3819d287da43678b7099d2e3828dd1
Source dataset
uspto-grants-2008_06
Patent number
US07390923B2

Reaction notes

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