反应详情

温度

50 °C

A mixture of (E)-tert-butyl (4-acetamido-3,5-dichlorobenzylamino)(3-hydroxy-3-(4-methoxyphenyl)propanamido)methylenecarbamate (26 mg) and MnO2 in dichloromethane (0.10 mL) was stirred at 50° C. for 12 h. The crude reaction mixture was filtered and concentrated under vacuum to give the title compound as a yellow sticky oil (17 mg, 66% yield). 1H NMR (400 MHz, CDCl3) δ 1.43-1.51 (9H, m), 1.11 (3H, s), 3.76-3.90 (5H, m), 4.35-4.69 (2H, m), 6.75-7.25 (4H, m), 7.26-7.90 (3H, m), 8.70 (1H, brd s), 11.90 (1H, brd s). HPLC retention time: 2.775 min (method A). MS (ESI) (M+H)+ 551.01.

1. customThe crude reaction mixture
2. filtrationwas filtered
3. concentrationconcentrated under vacuum