3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine

HRID 1337972ノート

反応式

HRID 1337972 の反応式
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC(C)(C)[O-].CC(C)[C@@H]1COC(c2cccc(C3=N[C@H](C(C)C)CO3)n2)=N1.CS(C)=O.[Cu][I].[K+]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

参加物

9

反応物 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

生成物 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine収率 19.678%HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridine収率 21.538%

試薬・触媒・溶媒 4

HCID 23665647Potassium tert-butoxide試薬HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 688213(R,R)-2,6-Bis(4-isopropyl-2-oxazolin-2-yl)pyridine触媒HCID 679Dimethyl Sulfoxide溶媒5 回

反応条件

温度
60 °C

後処理

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

出典と根拠

ORDレコード
ord-e4502d126ce540ee8526230598cb6dfa
出典データセット
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
元リンク
出典を表示

反応ノート

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