HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1337974Generated: October 25, 2026
3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine
https://huagongshe.com/reaction/1337974
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | Potassium tert-butoxide | HCID 23665647 | — |
| Catalyst | copper(I) bromide | HCID 24593 | — |
| Catalyst | (R,R)-2,6-Bis(4-isopropyl-2-oxazolin-2-yl)pyridine | HCID 688213 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 21.34% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 22.255% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-7814a69756194e3eb6e8489453dd858f |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
