Hydrochloric Acid → HCID 58650155, compound

Participants

Reaction Steps

(2E,4S)-4-[(N-{(2S)-2-[(tert-butoxycarbonyl)(methyl)amino]-3-methyl-3-phenylbutyl}-3-methyl-L-valyl)(methyl)amino]-2,5-dimethyl-2-hexenoic acid (40 mg, 0.068 mmol, from reference example 21) is dissolved in dichloromethane (3 ml) and treated with 4N hydrogen chloride (0.068 ml, 0.27 mmol) at room temperature for 30 minutes. The reaction mixture is then concentrated in vacuo and triturated with ether to give a white solid (29 mg, 87%). The crude material is purified by reverse phase HPLC. MS [M+H] 488.62

Provenance & Evidence