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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1338622Generated: November 1, 2026

3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1338622

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
ReagentPotassium tert-butoxideHCID 23665647—
Catalyst1,10-Phenanthroline-5,6-dioneHCID 72810—
CatalystHCID 178486304HCID 178486304—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 12238022324.627%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 13988833723.295%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-e2b6ae1b92ba4aec9d1e1c273a2d913d
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions