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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1338744Generated: October 31, 2026

3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1338744

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
ReagentPotassium tert-butoxideHCID 23665647—
Catalyst4,7-Dimethoxy-1,10-phenanthrolineHCID 10462298—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 12238022331.264%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 13988833727.238%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-35f0286b6efa44278dbd5fd730dccec4
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions