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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1339071Generated: November 3, 2026

3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1339071

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
ReagentSodium t-butoxideHCID 23676156—
Catalyst4,7-Diphenyl-1,10-phenanthrolineHCID 72812—
CatalystHCID 178476681HCID 178476681—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 12238022318.079%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 13988833717.914%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-dd087253b1d64c53b7888033f33df1d5
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions