Methanol → Ethyl 2-(3-amino-5-bromo-4-hydroxyphenyl)-4-methylpentanoate

HRID 133947Notes

Reaction equation

HRID 133947 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH:12]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[CH2:18][CH:19]([CH3:20])[CH3:21])[cH:5][c:6]([N+:9]([O-:10])=[O:11])[c:7]1[OH:8].[CH3:24][OH:25].[H:22][H:23].[OH-:26].[OH-:27].[Pd+2:28]>>[Br:1][c:2]1[cH:3][c:4]([CH:12]([C:13](=[O:14])[O:15][CH2:16][CH3:17])[CH2:18][CH:19]([CH3:20])[CH3:21])[cH:5][c:6]([NH2:9])[c:7]1[OH:8]

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57995502Ethyl 2-(3-bromo-4-hydroxy-5-nitrophenyl)-4-methylpentanoateHCID 178418361HCID 178418361, compound

Product 1

HCID 57995566Ethyl 2-(3-amino-5-bromo-4-hydroxyphenyl)-4-methylpentanoate

Sources & evidence

ORD record
ord-93008e14d21e4779970579b522648c90
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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