HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1339953Generated: October 31, 2026
3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine
https://huagongshe.com/reaction/1339953
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Catalyst | Bis[2-(diphenylphosphino)phenyl] ether | HCID 4285986 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 20.005% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 19.953% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-14ee9459c45b41d7a13d972e2bff4e46 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
