反应详情

1 ml of developed Raney nickel was added to a methanol (5 ml) solution of 410 mg of t-butyl 2-(4-amino-2-((2′-fluorobiphenyl-4-yl)oxy)-5-nitrophenyl)pyrrolidine-1-carboxylate, and the reaction liquid was stirred in a hydrogen atmosphere at room temperature for 1 day. The catalyst was removed through filtration through Celite, and the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1) to obtain the entitled compound as a brown oily substance.

1. customthe reaction liquid
2. customThe catalyst was removed through filtration through Celite
3. customthe solvent was evaporated away under reduced pressure
4. customthe residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1)
5. customto obtain the entitled compound as a brown oily substance