HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1340131Generated: November 1, 2026
3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine
https://huagongshe.com/reaction/1340131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | Potassium tert-butoxide | HCID 23665647 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Catalyst | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 22.444% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 20.586% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-02ff17137f614551a497958dc4dcbb4e |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
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