HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1340611Generated: October 31, 2026
3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine
https://huagongshe.com/reaction/1340611
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Catalyst | 4,4'-Dibromo-2,2'-bipyridine | HCID 15569987 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 17.64% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 18.154% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-85d32cb7f7e2421699cbf823cfe5481d |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
