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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1340638Generated: November 2, 2026

3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1340638

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
ReagentSodium t-butoxideHCID 23676156—
Catalyst4,7-Dichloro-1,10-phenanthrolineHCID 219391—
CatalystHCID 178486304HCID 178486304—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 12238022315.982%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 13988833715.904%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-7ef2dfe38da84514b154161925828d18
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions