HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-hydroxypyridine → 6-(1-Acetyl-5-methylpyrrolidin-2-yl)-5-((6-methylpyridin-3-yl)oxy)-2-pyridin-2-yl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-hydroxypyridine | HCID 14275 | — |
| Reactant | N-(4-(1-acetyl-5-methylpyrrolidin-2-yl)-5-fluoro-2-nitrophenyl)pyridine-2-carboxamide | HCID 23145552 | — |
| Product | 6-(1-Acetyl-5-methylpyrrolidin-2-yl)-5-((6-methylpyridin-3-yl)oxy)-2-pyridin-2-yl-1H-benzimidazole | HCID 23145192 | — |
Reaction Steps
The entitled compound was obtained as a pale yellow solid in the same method as in Example 338 (step 5) or in accordance with the method or by combining it with an ordinary method but using N-(4-(1-acetyl-5-methylpyrrolidin-2-yl)-5-fluoro-2-nitrophenyl)pyridine-2-carboxamide obtained in Example 545 and 6-methylpyridin-3-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728025B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e9a8116868f6419094ed6c0955c19366 |
| Source note | uspto-grants-2010_06 |