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Methanamine, N-methoxy-, hydrochloride (1:1) → 2-fluoro-N-methoxy-N-methylbenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 反応物 | 2-Fluoro-4-nitrobenzoic acid | HCID 302679 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-fluoro-N-methoxy-N-methylbenzamide | HCID 18357556 | — |
反応手順
5.79 g of N-methoxy-N-methylamine hydrochloride and 12.4 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (80 ml) suspension of 10 g of 2-fluoro-4-nitrobenzoic acid, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and water was added to it. The resulting deposit was taken out through filtration, washed with water, and dried to obtain the entitled compound as a pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728025B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-76d5f9db0bc242af8f1bbe578660f790 |
| 出典メモ | uspto-grants-2010_06 |