Water → 4-[4-(4-Methanesulfonyl-phenylamino)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 134227Notes

Reaction equation

HRID 134227 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17]3[c:18]2[n:19][cH:20][n:21][c:22]3[Cl:23])[CH2:12][CH2:13]1.[CH3:24][S:25](=[O:26])(=[O:27])[c:28]1[cH:29][cH:30][c:31]([NH2:32])[cH:33][cH:34]1.[OH2:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[n:15][cH:16][c:17]3[c:18]2[n:19][cH:20][n:21][c:22]3[NH:32][c:31]2[cH:30][cH:29][c:28]([S:25]([CH3:24])(=[O:26])=[O:27])[cH:34][cH:33]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 962WaterHCID 796174-(Methylsulfonyl)anilineHCID 57964905Tert-butyl 4-(4-chloro-1H-pyrazolo[3,4-D]pyrimidin-1-YL)piperidine-1-carboxylate

Product 1

HCID 532577914-[4-(4-Methanesulfonyl-phenylamino)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-4de47ff992af416c897bc43ce371b516
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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