HCID 23145775, compound → 6-((2R,5S)-1-acetyl-5-methylpyrrolidin-2-yl)-5-((6-(methoxymethyl)pyridin-3-yl)oxy)-2-pyrazin-2-yl-1H-benzimidazole

HRID 13429Notes

Reaction equation

HRID 13429 reaction equation
[C:1]([N:4]1[C@@H:8]([CH3:9])[CH2:7][CH2:6][C@@H:5]1[C:10]1[C:15](F)=[CH:14][C:13]([NH:17][C:18]([C:20]2[CH:25]=[N:24][CH:23]=[CH:22][N:21]=2)=O)=[C:12]([N+:26]([O-])=O)[CH:11]=1)(=[O:3])[CH3:2].[CH3:29][O:30][CH2:31][C:32]1[N:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=1>>[C:1]([N:4]1[C@@H:8]([CH3:9])[CH2:7][CH2:6][C@@H:5]1[C:10]1[C:15]([O:38][C:35]2[CH:36]=[N:37][C:32]([CH2:31][O:30][CH3:29])=[CH:33][CH:34]=2)=[CH:14][C:13]2[N:17]=[C:18]([C:20]3[CH:25]=[N:24][CH:23]=[CH:22][N:21]=3)[NH:26][C:12]=2[CH:11]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 23145775HCID 23145775, compoundHCID 67482980N-(4-((2R,5S)-1-acetyl-5-methylpyrrolidin-2-yl)-5-fluoro-2-nitrophenyl)pyrazine-2-carboxamide

Product 1

HCID 674826836-((2R,5S)-1-acetyl-5-methylpyrrolidin-2-yl)-5-((6-(methoxymethyl)pyridin-3-yl)oxy)-2-pyrazin-2-yl-1H-benzimidazole

Procedure

The entitled compound was obtained as a pale yellow oily substance in the same method as in Example 595 (step 9) or in accordance with the method or by combining it with an ordinary method but using N-(4-((2R,5S)-1-acetyl-5-methylpyrrolidin-2-yl)-5-fluoro-2-nitrophenyl)pyrazine-2-carboxamide obtained in Example 595 (step 8) and 6-(methoxymethyl)pyridin-3-ol.

Workup

  1. customThe entitled compound was obtained as a pale yellow oily substance in the same method as in Example 595 (step 9) or in accordance with the method

Sources & evidence

ORD record
ord-b682b7afe3df43709833da94ddeabd27
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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