3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1343499Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1343499
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>C=[CH](C)->[Pd]1<-[Cl][Pd](<-[Cl]1)<-[CH](=C)C.CN(C)c1ccccc1-c1ccccc1P(c1ccccc1)c1ccccc1.COCCOCCOC.C[Si](C)(C)[O-].[Na+]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

Komponenten

9

Edukt 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

Produkt 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridineAusbeute 0 %HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23672319Sodium trimethylsilanolateReagenzHCID 27349392'-(diphenylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amineKatalysatorHCID 178461822HCID 178461822, VerbindungKatalysatorHCID 8150DiglymeLösungsmittel5×

Reaktionsbedingungen

Temperatur
30 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-629e0d41273d456f8ff65497316f019b
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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