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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1344125Generated: November 2, 2026

4-Phenylpiperidine → 4-(4-Phenylpiperidin-1-yl)pyridine

https://huagongshe.com/reaction/1344125

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-PhenylpiperidineHCID 69873—
Reactant3-IodopyridineHCID 70714—
ReagentSodium t-butoxideHCID 23676156—
Catalyst1,3-BIS-(ADMANT-1-YL)-BENZIMIDAZOLIUM CHLORIDEHCID 16218257—
CatalystHCID 178505380HCID 178505380—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802230%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 13988833724.891%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-89ea336847584d9692e9d6b6efd0d691
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions