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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1344142Generated: October 30, 2026

4-Phenylpiperidine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1344142

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-PhenylpiperidineHCID 69873—
Reactant3-IodopyridineHCID 70714—
ReagentCID 21226062HCID 21226062—
Catalystpalladium(II) acetateHCID 167845—
CatalystDiethyl [2,2'-bipyridine]-4,4'-dicarboxylateHCID 12088573—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802230%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883370%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-02645cf819594c15a51afa3ef784034d
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions