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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1344337Generated: October 30, 2026

4-Phenylpiperidine → 4-(4-Phenylpiperidin-1-yl)pyridine

https://huagongshe.com/reaction/1344337

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-PhenylpiperidineHCID 69873—
Reactant3-IodopyridineHCID 70714—
ReagentSodium trimethylsilanolateHCID 23672319—
Catalyst4,7-Diphenyl-1,10-phenanthrolineHCID 72812—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802230%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 13988833710.297%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-849e7c29a30e4d5cacf7ce061a29fa9c
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions