反应详情

A solution of tert-butyl 4-[4-(methylamino)-3-nitrophenoxy]pyridine-2-carboxylate (1 eq) and 10% palladium on carbon (0.1 eq) in methanol was stirred at room temperature and flushed with nitrogen. Hydrogen was flushed through the reaction for 1-2 hours or until the reaction was determined to be complete by HPLC. Nitrogen was flushed through the reaction for 15 minutes before the reaction was filtered through a celite pad. The celite pad was washed with excess methanol followed by concentration under reduced pressure to afford the product as a light yellow solid. MS: MH+=316.

1. customflushed with nitrogen
2. customHydrogen was flushed through the reaction for 1-2 hours or until the reaction
3. customNitrogen was flushed through the reaction for 15 minutes before the reaction
4. filtrationwas filtered through a celite pad
5. washThe celite pad was washed with excess methanol
6. concentrationfollowed by concentration under reduced pressure