HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1345038Generated: November 2, 2026
4-Phenylpiperidine → 4-(4-Phenylpiperidin-1-yl)pyridine
https://huagongshe.com/reaction/1345038
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | 3-Iodopyridine | HCID 70714 | — |
| Reagent | Sodium trimethylsilanolate | HCID 23672319 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | L-Proline | HCID 145742 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 0% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 3.161% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-0def3b714bbe448eb40ec447e9ec2605 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
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