HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1345052Generated: October 30, 2026
4-Phenylpiperidine → 4-(4-Phenylpiperidin-1-yl)pyridine
https://huagongshe.com/reaction/1345052
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | 3-Iodopyridine | HCID 70714 | — |
| Reagent | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | N1,N2-bis(4-hydroxy-2,6-dimethylphenyl)oxalamide | HCID 126500385 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 0% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 18.99% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-5e23c0bbfa42411584777087bbca145f |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
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