化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 2-Chloro-5-methoxy-1,3-benzoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | HCID 178488270 | HCID 178488270 | — |
| 生成物 | 2-Chloro-5-methoxy-1,3-benzoxazole | HCID 11819712 | — |
反応手順
The mixture containing 5-methoxybenzoxazole-2-thiol was heated in thionyl chloride with a drop of DMF. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried and concentrated. Purification on a silica gel column gave 2-chloro-5-methoxybenzoxazole as a white solid. MS: MH+=184.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728010B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-72ee57f529fb4716b4fa5ff71406d94e |
| 出典メモ | uspto-grants-2010_06 |