HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoaniline → (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoaniline | HCID 7807 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-5-methoxy-1,3-benzoxazole | HCID 11819712 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (4-Bromophenyl)(5-methoxybenzoxazol-2-yl)amine | HCID 22040817 | — |
Reaction Steps
The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728010B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-9bac4797f8dc4d1cae695a5979e23f2d |
| Source note | uspto-grants-2010_06 |