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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1345746Generated: November 1, 2026

4-Phenylpiperidine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1345746

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-PhenylpiperidineHCID 69873—
Reactant3-IodopyridineHCID 70714—
ReagentCID 21226062HCID 21226062—
Catalystcopper(I) bromideHCID 24593—
Catalyst2,3,4,5,6-Pentafluoroanilino(oxo)acetic acidHCID 115564805—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 122380223101.637%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883370%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-df2c4c6f14284a74a68070b6326ae752
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions